What is a thyroid function test?
Thyroid
function tests are blood tests that check the levels of the hormones
(chemicals) made by the thyroid gland. Some thyroid function tests also
check the level of a hormone made by the pituitary gland in the brain,
which acts on the thyroid gland.
What is the thyroid?
The thyroid is a gland found in the neck. Its main function is to make hormones.
Hormones
are chemicals which are released into the bloodstream. They act as
messengers, affecting cells and tissues in distant parts of your body.
Thyroid hormones affect the body's metabolic rate and the levels of
certain minerals in the blood.
What does the thyroid do?
The
thyroid makes three hormones that it secretes into the bloodstream. Two
of these hormones, called thyroxine (T4) and triiodothyronine (T3),
increase your body's metabolic rate. The other hormone helps to control
the amount of calcium in the blood.
In order to make T3 and T4,
the thyroid gland needs iodine, a substance found in the food we eat. T4
is called this because it contains four atoms of iodine. T3 contains
three atoms of iodine. In the cells and tissues of the body most T4 is
converted to T3. T3 is the more active hormone; it influences the
activity of all the cells and tissues of your body.
How does the thyroid work?
The
main job of the thyroid gland is to produce hormones T4 and T3. To do
this the thyroid gland has to take a form of iodine from the bloodstream
into the thyroid gland itself. This substance then undergoes a number
of different chemical reactions which result in the production of T3 and
T4.
The activity of the thyroid is controlled by hormones
produced by two parts of the brain, the hypothalamus and the pituitary.
The hypothalamus receives input from the body about the state of many
different bodily functions. When the hypothalamus senses levels of T3
and T4 are low, or that the body's metabolic rate is low, it releases a
hormone called thyrotropin-releasing hormone (TRH). TRH travels to the
pituitary via the connecting blood vessels. TRH stimulates the pituitary
to secrete thyroid-stimulating hormone (TSH).
TSH is released
from the pituitary into the bloodstream and travels to the thyroid
gland. Here TSH causes cells within the thyroid to make more T3 and T4.
T3 and T4 are then released into the bloodstream where they increase
metabolic activity in the body's cells.
High
levels of T3 stop the hypothalamus and pituitary from secreting more of
their hormones. In turn this stops the thyroid producing T3 and T4.
This system ensures that T3 and T4 should only be made when their levels
are too low.
How do thyroid function tests work?
There
are several different types of thyroid function tests which may be
carried out. Interpreting all the different tests is complicated as
there are various conditions which can change the level of these
hormones. A rough guide to the different types of tests and their
interpretation is given below. However, your doctor or specialist doctor
should explain individual test results.
Usually the first test to
check thyroid function measures the levels of TSH in your blood. In
people with hypothyroidism (underactive thyroid) the amount of TSH will
usually be high. This is usually because the thyroid is not making
enough T3 to stop the pituitary producing TSH. If the level of TSH is
high, you will usually have further tests to check the levels of T3 and
T4 in the blood.
In people with hyperthyroidism (overactive
thyroid) the level of TSH will usually be low. This is usually because
the thyroid gland is making too much of its hormones. When levels of T3
and T4 are high, the pituitary is 'turned off' and the amount of TSH
produced is less. If you are found to have low levels of TSH you may
have some more blood tests to check the levels of T3 and T4 in the
blood. These tests may help doctors to find a specific cause of the low
TSH.
What are thyroid function tests used for?
Thyroid
function tests are usually done to find out whether the thyroid gland
is working properly. . Thyroid function tests can also be done to:
- Monitor treatment with thyroid replacement medicine for people who have hypothyroidism.
- Check thyroid gland function in people who are being treated for hyperthyroidism.
- Screen newborn babies for inherited problems with the thyroid.
What happens during a thyroid function test?
A
thyroid function test is a simple blood test. The blood sample is then
sent to the laboratory for analysis, and the results are sent back to
the doctor who asked for the tests.
What should I do to prepare for a thyroid function test?
Thyroid
function tests usually require very little preparation. Tell your
doctor if you are taking any medication as some drugs can alter the test
results and how they are interpreted. It is also important to mention
if you have had any X-ray tests that have used a special contrast dye as
this may contain iodine which can affect the results. Levels of thyroid
hormones also change in pregnancy, so tell your doctor if you are
pregnant when the test is taken.
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